5  inv(3) AML

5.1 Monosomy 7 and inv(3)

5.2 Central Diabetes Insipidus in inv(3)

• Here is an interesting study look at this association. Five cases reported in the literature (Cull et al. 2014)

Treatment options

5.3 Lenalidomide and HMA

• This is the study(Merz et al. 2020)

Cull, Elizabeth H., Justin M. Watts, Martin S. Tallman, et al. 2014. “Acute Myeloid Leukemia Presenting with Panhypopituitarism or Diabetes Insipidus: A Case Series with Molecular Genetic Analysis and Review of the Literature.” Leukemia & Lymphoma 55 (9): 2125–29. https://doi.org/10.3109/10428194.2013.869327.

Merz, Lauren E., Anthony J. Perissinotti, Bernard L. Marini, et al. 2020. “Lenalidomide Plus Hypomethylating Agent as a Treatment Option in Acute Myeloid Leukemia with Recurrent Genetic AbnormalitiesAML with Inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2, MECOM.” Clinical Lymphoma Myeloma and Leukemia 20 (1): 24–30. https://doi.org/10.1016/j.clml.2019.09.615.